Prognostic factors analysis of brainstem glioma

Abstract

Objeetive A retrospective analysis was carried out to evaluate the prognosis and Influence factors of brain stem gliomas (BSG).Methods From Jul.2009 to Dec.2011,54 patients with pathological diagnosis of WHOⅠ ～ Ⅳ BSG received definitive radiotherapy and eligible for the analysis.In all patients,21 cases accepted subtotal resection,27 cases accepted partial resection and 6 accepted biopsy; 16 cases accepted intensity-modulated radiation therapy (IMRT) and 38 cases accepted three dimensional radiotherapy(3DCRT),1.8～2.0 Gy/f,total dose(DT) was 45 ～60 Gy,the median DT was 50.4 Gy; 24 cases accepted concurrent chemoradiotherapy of temozolomide and 30 cases accepted radiation alone.The significance of related prognostic factors were evaluated by univariate and multivariate analysis.The value of each prognostic factor in the survival was added up to calculate the prognostic index(PI).Results In all patients,the median survival time was 17.5 months.The overall survival rate of 1 year and 3 year was 83％ and 61％,respectively.Univariate and multivariate analysis showed that with a low WHO grade and lesion confined to a single anatomic site gave a better survival.Conclusion Low WHO grade and lesion confined to a single anatomic site are likely to be independent prognostic factors.Prognostic index model can predict the prognosis of BSG more effectively than single variable. Key words: Brain stem gliomas ; Radiotherapy ; Temozolomide ; Prognosis