Abstract
Aims: To assess the clinical, pathological and molecular characteristics (Sonic hedgehog andgroup 3/4 molecular subtypes expression) and treatment modalities for infantile medulloblastoma in correlation with outcomes. Materials & methods: A retrospective study of 86medulloblastoma patients (≤3years) was conducted. M0 patients <2.5years received four cycles of chemotherapy followed by focal radiotherapy (FRT)and chemotherapy. Between 2007 and2015, Metastaticpatients <2.5years received craniospinalirradiation (CSI) after the end of chemotherapy. After 2015, metastatic patients <2.5years received CSI postinduction. Results: The hazard ratio for death was significantly higher in theFRT (HR=2.8) groupcompared with the CSI group (hazard ratio=1). Metastatic diseasesignificantly affected the overall survivalof the Sonic hedgehog groupand the overall survivaland event-free survival of group 3/4. Conclusion: Metastatic disease had a significant impact on outcomes. FRT is not effective in treating infantile medulloblastoma.
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