Abstract
Objective To analyze the prognostic evaluation value of plasma soluble myeloid cells trigger receptor 1 (sTREM-1), soluble vascular endothelial growth factor receptor (sFLT-1) and acute physiology and chronic health conditions (APACHE Ⅱ) score score in patients with severe pneumonia. Methods Forty-eight cases of patients with severe pneumonia was from December 2015 to June 2017, according to the disease outcome.They were divided into death group (n=16) and survival group (n=32), 50 patients with common pneumonia were selected in the same period, 47 healthy subjects were used as control group.We compared plasma sTREM-1, sFLT-1 and APACHE Ⅱ score changes between each groups and analyzed the correlation between the link, and prognosis. Results Plasma sTREM-1, sFLT-1 and APACHE Ⅱ score of plasma severe pneumonia group were significantly higher than ordinary pneumonia group and higher than the control group, which showed significant differences (P<0.05). Plasma sTREM-1, sFLT-1 and APACHE Ⅱ score of death group were significantly higher than the survival group same period, plasma of sTREM-1, sFLT-1 and APACHE Ⅱ score in death group were obviously rised, survival group obviously decreased, which showed significant differences (P<0.05). Plasma sTREM-1, sFLT-1, APACHE Ⅱ scores were positively correlated (r=0.761, 0.612, both P< 0.05); Plasma sFLT-1 with APACHE Ⅱ scores was positively correlated (r=0.604, P<0.05). The multi-factor logistic regression analysis showed the plasma and sTREM-1, sFLT-1, APACHE Ⅱscores were rating risk factors which affected the independence of the patients died. Conclusions Plasma sTREM-1, sFLT-1 and APACHE Ⅱ score can show the condition of patients with severe pneumonia, dynamic observation of the changes is helpful for prognosis judgement, which can guide clinical treatment. Key words: Severe pneumonia; Soluble medullary cells trigger the receptor-1; Soluble vascular endothelial growth factor receptor-1; Acute physiological and chronic health status scoring system; Prognosis
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