Abstract
Recent studies have shown that overexpression of metastasis-associated in colon cancer 1 (MACC1) is significantly associated with adverse prognoses of patients with different kinds of cancer. However, the exact survival effect of MACC1 on epithelial ovarian cancer (EOC) patients has not yet been established. Thus, the objective of this study was to explore the prognostic role of MACC1 mRNA in EOC by using Kaplan-Meier (KM) plotter and ONCOMINE database. Our results indicated that MACC1 mRNA high expression was significantly associated with unfavorable overall survival (hazard ratio (HR) = 1.51 (95% confidence interval (CI): 1.21 – 1.88), P = 0.00025) and progression-free survival (HR = 1.53 (95% CI: 1.24 – 1.89), P = 5.8e-05) in EOC patients. We also found that the expression of MACC1 mRNA in EOC was 2.5 times higher than that in normal surface ovarian epithelium, which was statistically significant (P = 2.86e-7). Our results suggest that MACC1 expression might be a biomarker for poor prognosis in individual EOC patients.
Highlights
It has been estimated that there will be about 22,240 new ovarian cancer patients diagnosed and approximately 14,070 ovarian cancer deaths in the US in 2018 [1]
KM plot curves showed that high expression of Metastasis-associated in colon cancer 1 (MACC1) mRNA was significantly correlated with poor overall survival (OS) in 655 patients with epithelial ovarian cancer (EOC) (HR = 1.51, P = 0.00025) (Figure 1(a))
MACC1 mRNA high expression was significantly correlated with poor OS in 523 cases with serous carcinoma (HR = 1.48, P = 0.0014) and in 30 patients with endometrioid carcinoma (HR = 7.31, P = 0.043)
Summary
It has been estimated that there will be about 22,240 new ovarian cancer patients diagnosed and approximately 14,070 ovarian cancer deaths in the US in 2018 [1]. Epithelial ovarian cancer (EOC) causes the majority of cancer-related deaths, despite recent development of treatment. It is critical to identify prognostic biomarkers that can predict the survival prognosis of individual EOC patients. Metastasis-associated in colon cancer 1 (MACC1) gene, a novel regulator of tumor growth and metastasis, has recently been identified in colon cancer [3]. Some studies have suggested that MACC1 overexpression is significantly associated with unfavorable clinical outcomes in various cancers [5,6,7,8,9]. The precise survival effect of MACC1 on EOC patients remains unclear
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