Abstract
Introduction (J.G.M. Klijn). The p53 tumour suppressor gene: from molecular biology to clinical investigation (T. Soussi). Subgroups of p53 mutations may predict the clinical behaviour of cancers in the breast and colon and contribute to therapy response (A.L. Borresen-Dale). Determination and use of p53 in the management of cancer patients, with special focus on breast cancer (J. Bergh). Prognostic and predictive significance of p53 protein accumulation in human primary breast cancer analysed with a luminometric assay (LIA) on tumour cytosols (E.M.J.J. Berns, J.A. Foekens, J.G.M. Klijn). p53 status: impact on breast tumour biology and response to therapy (R.M. Elledge, D.C. Allred). The prognostic significance and interactions of p53 in human cancer (J.J. Anderson et al.). p53 protein expression in human breast cancer: relationship to tumour differentiation and endocrine response (R.I. Nicholson et al.). p53 and angiogenesis in neoplasia (G. Gasparini, A.L. Harris). Prognostic and predictive value of p53 aberrations in tumours of the gastrointestinal tract and pancreas (G. Viale). p53 genotypes and haplotypes with a potentially predictive value for risk assessment and retroviral p53 transduction for gene therapy of breast cancer (I.B. Runnebaum).
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