Abstract
Osteopontin is an extracellular matrix protein which is produced by different types of cells and plays an important functional role in many biological processes. This review discusses the main functions of osteopontin, its role in the progression and chemoresistance of malignant neoplasms, in the regulation of epithelial-mesenchymal transition, angiogenesis, and the body’s immune response to the tumor. The article considers the currently known mechanisms by which osteopontin affects to the survival, mobility and invasion of tumor cells, to tumor sensitivity to drug treatment, as well as the prospects for a integrated study of the predictive significance of osteopontin, markers of hypoxia, angiogenesis, epithelial- mesenchymal transition, and immunological tolerance.
Highlights
Osteopontin is an extracellular matrix protein which is produced by different types of cells and plays an important functional role in many biological processes
This review discusses the main functions of osteopontin, its role in the progression and chemoresistance of malignant neoplasms, in the regulation of epithelial-mesenchymal transition, angiogenesis, and the body’s immune response to the tumor
The article considers the currently known mechanisms by which osteopontin affects to the survival, mobility and invasion of tumor cells, to tumor sensitivity to drug treatment, as well as the prospects for a integrated study of the predictive significance of osteopontin, markers of hypoxia, angiogenesis, epithelial-mesenchymal transition, and immunological tolerance
Summary
Contacts: Osteopontin is an extracellular matrix protein which is produced by different types of cells and plays an important functional role in many biological processes. В статье обсуждаются известные в настоящий момент механизмы, при помощи которых остеопонтин оказывает влияние на выживаемость, подвижность и инвазию опухолевых клеток, чувствительность опухоли к лекарственному лечению, а также представлены перспективы комплексного изучения предиктивной значимости этого белка, маркеров гипоксии, ангиогенеза, эпителиально-мезенхимального перехода и иммунологической толерантности. This review discusses the main functions of osteopontin, its role in the progression and chemoresistance of malignant neoplasms, in the regulation of epithelial-mesenchymal transition, angiogenesis, and the body’s immune response to the tumor.
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