Abstract
Circulating tumor cells (CTCs) play a crucial role in metastatic cascade, tumor dissemination, and progression. CTCs represent a unique biomarker, as they are cancer cells and sampling of a patient's tumor. CTCs are a heterogeneous cell population of tumor cells with different phenotypes and biological values, with established prognostic impact in primary and metastatic breast cancer. Detection and molecular profiling of CTCs could represent a valuable prognostic and predictive factor, a tool for tumor ‘liquid’ biopsy in real time and for personalized anticancer treatment. Several trials are ongoing aimed to demonstrate clinical utility of CTCs detection and profiling to facilitate rational treatment decisions for breast cancer patients. Therapeutic targeting of CTCs might be a promising strategy to interfere with metastatic cascade and tumor dissemination.
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