Abstract
Schistosomiasis is an infectious disease that affects more than 230 million people worldwide, according to conservative estimates. Some studies published from China and Japan reported that schistosomiasis is a risk factor for colorectal cancer in Asia where the infective species is S. japonicum. However, there have been only few reports of prognosis of patients with schistosomal rectal cancer SRC. This study aimed to analyze differences in prognosis between SRC and non-schistosomal rectal cancer(NSRC) with current treatments. A retrospective review of 30 patients with schistosomal rectal cancer who underwent laparoscopic total mesorectal excision operation (TME) was performed. For each patient with schistosomal rectal cancer, a control group who underwent laparoscopic TME with non-schistosomal rectal cancer was matched for age, gender and tumor stage, resulting in 60 cases and controls. Univariate analysis showed pathologic N stage (P=0.006) and pathologic TNM stage (P=0.047) statistically significantly correlated with disease-free survival (DFS). Pathologic N stage (P=0.014), pathologic TNM stage (P=0.002), and with/without schistosomiasis (P=0.026) were statistically significantly correlated with overall survival (OS). Schistosomiasis was the only independent prognostic factor for DFS and OS in multivariate analysis. The prognosis of patients with schistosomal rectal cancer is poorer than with non-schistosomal rectal cancer.
Highlights
Colorectal cancer (CRC) is the fourth most common carcinoma in China, and the morbidity was increasing rapidly (Gu et al, 2013)
Few studies reported the prognosis of patients with schistosomal rectal cancer
Some risk factors accounts for most cases of colorectal cancer such as smoking, drinking and obesity were analyzed (Brenner, 2014)
Summary
Colorectal cancer (CRC) is the fourth most common carcinoma in China, and the morbidity was increasing rapidly (Gu et al, 2013). Schistosomiasis was an infectious disease that affected more than 230 million people worldwide, according to conservative estimates (Vos et al, 2012). Some studies published from China (Xu and Su, 1984) and Japan (Ishii et al, 1994) reported that schistosomiasis was a risk factor for colorectal cancer in Asia where the infective species was S. japonicum. Few studies reported the prognosis of patients with schistosomal rectal cancer. Schistosomiasis is an infectious disease that affects more than 230 million people worldwide, according to conservative estimates. Some studies published from China and Japan reported that schistosomiasis is a risk factor for colorectal cancer in Asia where the infective species is S. japonicum. There have been only few reports of prognosis of patients with schistosomal rectal cancer SRC. Conclusions: The prognosis of patients with schistosomal rectal cancer is poorer than with non-schistosomal rectal cancer
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