Abstract
The purpose of this study was to demonstrate the prognostic role of inflammatory biomarkers in patients with laryngeal squamous cell carcinoma. For this study, we enrolled 151 patients who had undergone surgery for laryngeal squamous cell carcinoma. We assessed the preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), mean platelet volume, red cell distribution width, and alkaline phosphatase. The chi-square test, Kaplan-Meier survival analysis, and Cox proportional hazards model were conducted on overall survival, progression-free survival, locoregional recurrence-free survival, and distant metastasis-free survival of patients with laryngeal squamous cell carcinoma. Both Kaplan-Meier analysis and univariate analysis showed significant prognostic differences with age, laryngectomy methods, Tumor Node Metastasis (TNM) staging, tumor location, NLR, PLR, MLR, and mean platelet volume. Multivariate analysis indicated that NLR (overall survival: hazard ratio [HR] = 3.02, 95% confidence interval [CI]: 1.28-7.10, P = .011), PLR (overall survival: HR = 0.33, 95% CI: 0.14-0.78, P = .011; progression-free survival: HR = 0.016,95% CI: 0.10-0.79, P = .016), and MLR (overall survival: HR = 0.29, 95% CI: 0.11-0.76, P = .012) were independent prognostic factors for 5-year survival. However, red cell distribution width and alkaline phosphatase had no significant difference in overall survival and progression-free survival. Preoperative high NLR, PLR, and MLR were associated with poor prognosis. They were found to be effective and reliable inflammatory biomarkers for patients with laryngeal squamous cell carcinoma.
Highlights
Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck malignancies with poor prognosis
Red cell distribution width and alkaline phosphatase had no significant difference in overall survival and progression-free survival
Preoperative high neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR) were associated with poor prognosis
Summary
Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck malignancies with poor prognosis. Its. 5-year survival rate is approximately 75% in patients with localized disease, 44% in patients with regional disease, and. 35% in patients with distant disease.[1] When there is regional or distant metastasis, the 5-year survival rate drops significantly. Laryngeal squamous cell carcinoma accounts for 85% to 95%. Of all laryngeal carcinomas, and the age of onset for this disease is earlier than it was in the past.[2] it is appropriate to urgently find effective and reliable biomarkers that will help in predicting the prognosis of LSCC, the possibility of recurrence, and the nature of distant metastasis.
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