Abstract
背景与目的目前,肺叶切除与亚肺叶切除治疗Ia期小细胞肺癌(small cell lung cancer, SCLC)的预后比较鲜有报道。本研究通过对年龄≥60岁的T1N0M0(≤3 cm)SCLC进行回顾性研究,旨在探索肺叶切除与亚肺叶切除治疗Ia期SCLC预后的对比分析。方法纳入“监测,流行病学和结果数据库”(Surveillance, Epidemiology and End Results database, SEER)在1992年-2010年间经病理诊断为Ia期SCLC患者共515例,数据使用Kaplan-Meier(Log-rank检验)和Cox模型进行比较统计分析。结果肺叶切除组(n=110)、亚肺叶切除组(n=57)、和非手术治疗组(n=348)的中位生存期分别为45个月、23个月和16个月;该三组相应的5年总生存期(OS)分别为44%、30%和14%(Lob vs Sub, χ2=4.851, P=0.028; Sub vs non-surgical, χ2=6.529, P=0.011)。SCLC有、无淋巴结采样/清扫患者的预后无显著差异(P=0.107);肺叶切除+放化疗组(Lob+CR, n=59)的5年OS为50%。Cox分析证实,手术(肺叶与亚肺叶切除术)方式为独立预后预测因素之一。结论年龄≥60岁的Ia期SCLC患者,我们推荐解剖性肺叶切除联合辅助放化疗治疗。
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.