Abstract
BackgroundMany patients with gastric gastrointestinal stromal tumor (GIST) and synchronous gastric cancer have been described, most in single case studies. We retrospectively investigated the clinicopathologic features and prognostic effects of gastric GIST in patients with synchronous gastric cancer.MethodsThe study enrolled 170 patients with gastric GIST, who had undergone complete surgical resection (R0) from January 2000 to December 2011. Forty-two patients had synchronous gastric cancer (CA Group), whereas 128 did not (Non-CA Group). The clinicopathologic features and potential prognostic factors in the two groups were compared.ResultsPatients in the CA Group had more obvious symptoms, but a lower rate of preoperative diagnosis of gastric GIST (P <0.05). The two groups differed significantly in gender, age, greatest tumor diameter, risk stratification, tumor-associated ulcers, and CD117 and CD34 expression (P <0.05 each). Univariate analysis showed that age, risk stratification, postoperative oral imatinib and synchronous gastric cancer were predictive factors of survival (P <0.05). Cox regression analysis showed that risk stratification, postoperative oral imatinib and synchronous gastric cancer were independent predictors of survival (P <0.05). Stratified analysis showed that the 5-year overall survival rate was lower in patients with synchronous gastric cancer than in those without synchronous gastric cancer.ConclusionsGastric GIST with synchronous gastric cancer had a lower rate of preoperative diagnosis, with correct diagnosis often missed. Survival, however, depended primarily on the gastric cancer.
Highlights
Many patients with gastric gastrointestinal stromal tumor (GIST) and synchronous gastric cancer have been described, most in single case studies
Compared with the Non-CA Group, the CA Group had a higher percentage of males, was older in age, and had a lower frequency of ulcer, a smaller greatest tumor diameter, lower risk stratification, and lower positivity rates for CD117 and CD34, with all of these differences being statistically significant (Table 1)
Cox regression analysis showed that risk stratification, postoperative oral imatinib and synchronous gastric cancer were independent predictors of overall survival (OS) (P
Summary
Many patients with gastric gastrointestinal stromal tumor (GIST) and synchronous gastric cancer have been described, most in single case studies. We retrospectively investigated the clinicopathologic features and prognostic effects of gastric GIST in patients with synchronous gastric cancer. Since the first report of synchronous epithelial and stromal tumors in the stomach in 2000, [1] many patients with gastric GIST and synchronous gastric cancer have been described, most in single case studies [2,3,4,5,6,7,8]. Little is known about the synchronous GIST and gastric cancer. We retrospectively compared clinicopathologic findings and prognostic factors in patients with primary GIST with those in patients with primary GIST and synchronous gastric cancer
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