Prognostic analysis of 53 patients with multiple primary upper gastrointestinal cancer

Abstract

Objective To investigate the clinical characteristics, the principles of diagnosis, treatment and the prognosis of primary esophageal cancer. Methods 53 patients with esophageal cancer were analyzed, including in 28 cases of synchronous carcinoma (SC) and 25 cases of metachronous carcinoma (MC). 8 patients received simple operation without following chemotherapy, 28 patients with esophageal and stomach lesion were treated by operation and radiation and chemotherapy, and only 17 patients were treated with simple chemotherapy. Total cases were followed up for survival time. Results The 1-, 3-and 5-year survival rates were 64.3 % (18/28), 7.1 % (2/28), 7.1 % (2/28) in SC, and were 100.0 % (25/25), 80.0 % (20/25), 40.0 % (10/25) in MC (P<0.05). For different treatments, the 1-, 3-and 5-year survival rates were 75.0 % (6/8), 25.0 % (2/8), 25.0 % (2/8) in simple operation, 52.9 % (9/17), 0, 0 in simple chemoradiotherapy, and 100.0 % (28/28), 71.4 % (20/28), 35.7 % (10/28) in operation plus chemoradiotherapy. The results from multiple factors regression analysis showed that the pathogenesis, pathological type, the time interval of onset were the independent prognostic factors which can influence the survival time (chi square values were 1.330, 0.023, 0.056, all P<0.05). Conclusions MC patients have longer survival time and higher survival rate than SC patients. There is no difference of the 1-, 3-, 5-year survival rates of patients with different treatments. Key words: Multiple primary upper gastrointestinal cancer; Treatment; Prognosis