Prognostic analysis of 23 cases of undifferentiated thyroid carcinoma

Abstract

Objective: To investigate the relationship between clinical features, treatment and prognosis of undifferentiated thyroid carcinoma. Methods: The clinical and follow-up data of 23 patients with undifferentiated thyroid carcinoma admitted to Chongqing University Cancer Hospital from March 2012 to September 2019 were retrospectively analyzed. Results: The median survival time of 23 patients with undifferentiated thyroid carcinoma was 15 weeks, 3-month survival time was 56.5%, 6-month survival rate was 39.1%, and 1-year survival rate was 30.4%. Univariate analysis showed that the size of primary tumor lesion, normal albumin, normal platelets, activated partial thrombin time, fibrinogen, thyroglobulin antibody and radiotherapy were the factors influencing the prognosis of undifferentiated thyroid cancer. The analysis of the effect of treatment on the prognosis showed that surgery, radiotherapy and combined treatment can obviously improve the prognosis. Multivariate analysis showed that the independent factors affecting prognosis were the diameter of the primary lesion, whether radiotherapy was given or not, the dose of radiotherapy, and whether radiotherapy was combined with surgery. Conclusion: The malignant degree of undifferentiated thyroid cancer is very high, so R0 or R1 resection of neck lesions plus radiotherapy should be taken as far as possible for patients with surgical opportunity, and the same effect may be achieved for patients who have lost the surgical opportunity. Anticoagulant and antiplatelet therapy may benefit patients.