PROGNOSIS OF RENAL DYSFUNCTIONIN TERM NEWBORNS WITH PATHOLOGICAL COURSE OF EARLNEONATAL ADAPTATION

Abstract

Newborns getting treatment in the intensive care units constitute a high risk group concerning formation of renal dysfunction which serious sign is acutekidney injury. Objective: to develop a mathematical model toprognosticate renal dysfunction of term newborns considering degree of severity of pathological course of early neonatal adaptation. Materials and methods. A retrospective study was carried out including the analysis of risk factors ofrenal dysfunction in 80 term newborns with signs of perinatal pathology of different degree of severity with further step-by-step discriminant analysis of indexed factors (mother’s age ≥ 35 years, presence/absence ofchronic pathology of the urinary system, gestational pyelonephritis in mother, assessment of acute adaptation of a newborn by Apgar scale at the end of the first and fifth minute of life, presence/absence of arterial hypotension syndrome, assessment by NTISS, levels of diuresis by the hour and serum creatinine in a newborn). Results of the study. Coordinates of centroids by the main functions obtained by the findings of discriminant analysis for children without renal dysfunction were the following: F 1 =4,84; F =-0,36; for children with mild disorders – F 1 =0,42; F 2 2 =0,60; for children with moderate disorders – F 1 =-1,94; F =0,51; and for children with severe disorders – F 1 2 =-3,31; F =-0,75. Conclusion. The suggested mathematical model 2 to prognosticate disorders of the renal functional state in sick newborns enables to predict development of severe renal dysfunction to within 75,0%, moderate degree – 80,0%, mild degree – 85,0%, absence of renal dysfunction – 100,0%.