Abstract
Prostate cancer (PCa) is the leading cause of cancer-related death among men worldwide. Knowledge of the prognostic factors of PCa and the bone metastasis pattern of patients would be helpful for patients and doctors. The data of 177,255 patients with prostate cancer diagnosed between 2010 and 2013 with at least five years of follow-up were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Multivariate Cox regression analysis was used to determine the predictive value of patients’ characteristics for survival after adjusting for other variates. Multivariate logistic regression analysis was used to evaluate the odds ratio of bone metastasis in PCa patients. The predictive value of age, race, marital status, and tumor characteristics were compared. The survival of patients with different socioeconomic statuses and bone metastasis statuses was compared by Kaplan–Meier analysis. A total of 1,335 patients with prostate cancer diagnosed between 2009 and 2015 were enrolled from the Second Affiliated Hospital of Zhejiang University School of Medicine. The survival of patients with different prostate-specific antigen (PSA) levels, Gleason scores, marital statuses and bone metastasis statuses was compared by Kaplan-Meier analysis. In SEER database, 96.74% of patients were 50 years of age or older. Multivariate Cox analysis revealed that for PCa patients, age at presentation, older age, single marital status, lower socioeconomic status, higher PSA level, T1 and N0 stage, and bone metastasis were independent risk factors for increased mortality. Multivariate logistic regression analysis revealed that patients who were married, were living in urban areas, had lower PSA levels, underwent surgery, and radiation had lower OR factors for bone metastasis. Asian or Pacific Islander, better socioeconomic status, lived in urban areas, married marital status, lower PSA levels and lower Gleason scores were better prognostic factors in PCa. Additionally, patients with single or divorced marital status, who were living in rural places had higher PSA levels, and T1 and N0 stages have a high OR for bone metastasis.
Highlights
Prostate cancer (PCa) is one of the top ten leading causes of cancer-related death among men in China, the second in the United States, and the third in Europe[1,2,3]
We aimed to identify risk factors associated with cancer prognosis and to detect the bone metastasis pattern of PCa patients in SEER database and a Chinese hospital
Social and clinical tumor characteristics would both effect the overall survival (OS) of PCa
Summary
Prostate cancer (PCa) is one of the top ten leading causes of cancer-related death among men in China, the second in the United States, and the third in Europe[1,2,3]. 10% of newly diagnosed PCa patients present with bone metastasis, increasing to 80% at advanced stages of the disease[15,16]. Butler SS et al reported that the incidence of localized prostate cancer declined across age groups from 2012 to 2015, the incidence of distant metastatic disease increased gradually[17]. These metastases are associated with poor prognosis, bone pain, and pathological characteristics and indicate the incurability of disease in most cases[18]. We aimed to identify risk factors associated with cancer prognosis and to detect the bone metastasis pattern of PCa patients in SEER database and a Chinese hospital. The identification of the prognostic factors and pattern of bone metastasis in PCa may guide clinicians, researchers and patients to better understand this cancer
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
