Abstract
The authors examined 222 cytologic specimens from 60 patients with squamous cell carcinoma of the cervix, International Stages II and III, who were treated with radiation at the University of Minnesota Hospitals between 1964 and 1967. When evidence of postirradiation dysplasia (PRD) was found, the nuclear DNA content of the dysplastic cells was measured by two-wavelength Feulgen micro-spectrophotometry, with 20 morphologically normal intermediate squamous cells used as controls. On the basis of these measurements, occurrences of PRD were classified as diploid, polyploid, or aneuploid. Types of PRD were correlated with 5-year rates of recurrence of disease. The incidence of PRD, especially of the aneuploid type, was significantly higher in women who died within 5 years. Six of seven women with cytologic evidence of the aneuploid type of PRD had recurrent disease within 2 years. The data suggest that micro-spectrophotometry of cytologic samples might contribute to early detection of recurrent malignant disease, especially in patients who show evidence of aneuploid postirradiation dysplasia.
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