Abstract
A population based, controlled follow-up study of the general outcome of 73 children followed for 2 to 12 years after the acute phase of childhood encephalitis is reported from the University of Oulu, Finland.
Highlights
Autism is another unusual sequel to herpes simplex encephalitis described in a 31 year old adult at the University of Goteborg, Sweden
Herpes simplex encephalitis (HSE) followed a biphasic course with relapse in 3 children aged 11 years, 9 months, and 11 months reported from the Hospital for Sick Children, London and South Hampton General Hospital, England
A possible resistant organism might indicate a longer initial course of high dose acyclovir or alternatively, a post-infectious neuroallergy process might suggest the substitution of immunomodulatory treatment in place of further antiviral treatment
Summary
Herpes simplex encephalitis (HSE) followed a biphasic course with relapse in 3 children aged 11 years, 9 months, and 11 months reported from the Hospital for Sick Children, London and South Hampton General Hospital, England. A possible resistant organism might indicate a longer initial course of high dose acyclovir or alternatively, a post-infectious neuroallergy process might suggest the substitution of immunomodulatory treatment in place of further antiviral treatment The authors refer to 7 additional patients reported in the literature. Autism is another unusual sequel to herpes simplex encephalitis described in a 31 year old adult at the University of Goteborg, Sweden. Autism is not necessarily a developmental disorder and temporal lobe damage caused by herpes encephalitis may explain some cases. The Kluver-Bucy syndrome, characterized by emotional instability, hypersexuality and hyperorality, has been described as a complication of herpes encephalitis when both temporal lobes have been involved
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