Abstract

Investigators from Oxford John Radcliff Hospital and Great Ormond Street Hospital for Children performed a retrospective study of myasthenia patients diagnosed before the age of 16 years.

Highlights

  • Investigators from Oxford John Radcliff Hospital and Great Ormond Street Hospital for Children performed a retrospective study of myasthenia patients diagnosed before the age of 16 years

  • Seronegative patients were classified by clinical symptoms and standard electrophysiologic testing, repetitive nerve stimulation, single-fiber EMG, or both

  • Remission was more likely in patients who were seronegative or only had antibodies identified by clustered Acetylcholine Receptors (AChR) cell-based assay (CBA) than not

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Summary

Introduction

Investigators from Oxford John Radcliff Hospital and Great Ormond Street Hospital for Children performed a retrospective study of myasthenia patients diagnosed before the age of 16 years. Investigators looked at demographics, clinical features, neurophysiologic testing, and antibody testing to evaluate prognostic features. Antibodies were detected in a majority of patients (89%, 66/74). 52 (70%) were diagnosed via Radioimmunoprecipitation assay (RIA), and 10 (14%) were diagnosed by clustered Acetylcholine Receptors (AChR) in a cell-based assay (CBA).

Results
Conclusion
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