Abstract
Small artery occlusion (SAO) is the one of the primary subtype of ischemic stroke in China. However, its outcomes among elderly patients are unclear. Consecutive patients with SAO were recruited at Jiamusi University First Hospital, China between January 2008 and December 2016. Stroke subtype, severity, and risk factors were collected; outcomes at 3, 12, and 36 months after stroke onset were assessed. A total of 1464 SAO patients were included in this study. Participants aged ≥75 years had higher dependency rates than Participants aged <75 years with SAO in all three follow-up periods, in addition to a higher recurrence rate at 12 months and a higher mortality rate 36 months after stroke. After adjusting for confounders, elevated triglyceride level was found to be a protective factor against mortality 36 months after stroke. Stroke severity, diabetes mellitus, artery stenosis, gender, obesity, and high-density lipoprotein cholesterol level were independently associated with the risk of dependency; elevated triglyceride level was an independent risk factor for recurrence at 3 months point after stroke onset. These findings suggest that it is vital to manage risk factors that may affect prognosis of stroke among elderly patients with SAO to improve patient prognosis and reduce the burden of stroke in China.
Highlights
Stroke has been the primary cause of death and serious, long-term disability worldwide[1]
Little is known about outcomes and risk factors associated with outcomes among elderly patients with Small artery occlusion (SAO) among Chinese elderly patients
The prevalence rates of hypertension, atrial fibrillation, obesity, current smoking, and alcohol consumption were significantly higher in the elderly group than in the young group; similar trends were observed with levels of fasting plasma glucose (FPG), TG, and low-density lipoprotein cholesterol (LDL-C) (Table 1)
Summary
Stroke has been the primary cause of death and serious, long-term disability worldwide[1]. There has shown a decline trend in stroke incidence in developed countries over the last 30 years[2,3], stroke gradually raised to the leading cause of death and disability from 1990 to 2017 in China, accounting for almost one-third of the total number of deaths from stroke worldwide[4,5,6]. It is crucial to identify the different potential underlying causes of stroke subtype to targeted treatment and decrease the burden of stroke in China. In this study, we aimed to assess the clinical features, outcomes, and relevant risk factors 3, 12, and 36 months after stroke onset among elderly patients with SAO in China
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