Prognosis analysis of acute paraquat poisoning with early changes of white blood cells and neutrophils ratio

Abstract

Objective To investigate the correlation between the early changes of white blood cell count, neutrophil ratio and prognosis of patients with acute paraquat poisoning. Methods Nine hundred and fifty-four patients with acute paraquat poisoning were divided into survival group and death group according to prognosis. The early changes of white blood cell count and neutrophil ratio within 24 hours were observed, the correlation between the early changes of white blood cell count, neutrophil ratio and prognosis of patients with acute paraquat poisoning were analyzed. Results Of the 954 cases, 410 cases were survival, 544 cases were died, the mortality rate was 57.0%. Compared with the survival group, the white blood cell count [(19.22±8.37)×109/L vs (11.46±4.55)×109/L, P=0.001] and the neutrophils ratio [(92.98±3.02)% vs (85.31±9.02)%, P=0.000] in death group were significantly increased, the differences were statistically significant(P<0.05). Area under the curve(AUC) of white blood cell count was 0.813, sensitivity was 78.4%, specificity was 71.4%. AUC of neutrophils ratio was 0.846, sensitivity was 83.1%, specificity was 71.8%. AUC of the ROC showed that white blood cell count and neutrophil ratio can predict the prognosis of patients with acute paraquat poisoning. Conclusions Early white blood cell count and neutrophil ratio can be used to predict the prognosis of patients with acute paraquat poisoning. Key words: Paraquat; White blood cell count; Neutrophil ratio; Prognosis