Abstract
The study’s aim and the objective were to evaluate the association between progesterone receptor PROGINS and preterm delivery by correlating with clinical data. The study had begun with 150 preterm delivery cases (PTD) among which it has classified into 3 cohorts as extreme preterm i.e. 24 - 28 gestation weeks, n= 37, very preterm i.e. 28 to <32 gestation weeks, n =36; and late preterm i.e. 32 to <37 gestation weeks, n =77. 150 cases of term delivery were evaluated for progesterone receptor PROGINS gene polymorphism. Software R version 3.6.3 was used for the statistical analysis. PTD cases were having higher PR mutation. The mutant allele of T2 frequencies were .23 in preterm delivery women and .01 in controls with odds ratio 18.0 (CI, 4.25- 76.1). Homozygous for T2 allele was present in 2.6% of preterm delivery women. PROGINS polymorphisms had showed association in preterm labor and are evidently enhancing risky genetic factors in terms of the susceptibility of PTD.
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