Abstract
Reproductive Biology Cumulus cells surrounding the ovulated egg release the female hormone progesterone, which is necessary for sperm activation in mammals. Miller et al. identified the human sperm progesterone receptor as the orphan enzyme ABHD2. When bound by progesterone, the ABHD2 receptor acts as a lipid hydrolase to deplete an endocannabinoid inhibitor of the plasma membrane's calcium channel. This allows the entry of calcium ions through the calcium channel to activate sperm that are then primed for fertilization. Science , this issue p. [555][1] [1]: /lookup/doi/10.1126/science.aad6887
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