Abstract
Cytosol progesterone receptors (P-R) were measured in breast fibroadenomas from 88 women, and their levels were compared to the tumor epithelial cell density and estradiol receptor levels (E-R). Three groups of fibroadenoma were distinguished: type I with a high epithelial cell density ( n= 18), type III ( n = 46) with low epithelial cell density and extensive fibrosis, and type II with cell density intermediate between the two other groups ( n = 24). Whereas E-R levels correlated well with cellular density, P-R levels were elevated in group I and absent in group III, but in contrast to E-R, the low P-R levels observed in group II could not be only explained by cellular density. Since P-R is an estrogen-dependent protein and an hormonal marker, its decrease in type II fibroadenoma might be interpreted as reflecting a rapid decrease in hormone dependence.
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