Progesterone Receptor (PGR) gene polymorphism is associated with susceptibility to preterm birth.

Immaculate Mbongo Langmia,Siti Zawaih Omar,Zahurin Mohamed,Yamunah Devi Apalasamy

doi:10.1186/s12881-015-0202-1

Immaculate Mbongo Langmia, Siti Zawaih Omar + Show 2 more

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https://doi.org/10.1186/s12881-015-0202-1

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Journal: BMC Medical Genomics	Publication Date: Aug 19, 2015
Citations: 33	License type: cc-by

Affiliation: University of Malaya

Abstract

BackgroundPreterm birth (PTB) is the major cause of death in newborn and the second major cause of death in children less than 5 years old worldwide. Genetic polymorphism has been implicated as a factor for the occurrence of preterm birth. The aim of this study is to evaluate whether polymorphism in the progesterone receptor (PGR) is associated with susceptibility to preterm birth.MethodsA total of 135 women with preterm and 532 women with term deliveries were genotyped for PGR gene polymorphisms (rs660149, rs471767, rs10895068) using Sequenom MassARRAY platform.ResultsThe G allele of PGR rs660149 polymorphism was significantly associated with susceptibility to PTB in the Malay women. The odds of G allele occurring among Malay women with preterm delivery was twice that of Malay women with term delivery (OR 2.3, 95 % CI (1.2–4.5, P = 0.011). Alternatively, no significant association was observed between PGR rs660149 polymorphisms and susceptibility to PTB in Chinese and Indian women.ConclusionsThis study shows that variability in the occurrence of PTB across ethnicities in Malaysia is partly due to differences in genetic background. We therefore suggest that in addition to life style and environmental factors, genetic factor should be greatly considered in this population. Prior information on the genetic composition of women may help in the identification and management of women at risk of preterm birth complication.

Highlights

Preterm birth (PTB) is the major cause of death in newborn and the second major cause of death in children less than 5 years old worldwide
Malaysia is a multi-ethnic country consisting of three major ethnic groups, namely the Malays, Chinese and Indians, Langmia et al BMC Medical Genetics (2015) 16:63 each of which are of different genetic background, presenting a good opportunity to study the genetic disparity of preterm birth with regards to progesterone receptor (PGR) gene polymorphism
In this study we aim to explore the genetic influence of PGR gene polymorphisms on the risk of PTB among Malaysian women

Summary

Introduction

Preterm birth (PTB) is the major cause of death in newborn and the second major cause of death in children less than 5 years old worldwide. The aim of this study is to evaluate whether polymorphism in the progesterone receptor (PGR) is associated with susceptibility to preterm birth. Preterm birth is the major cause of death in the newborn and the second major cause of death in children less than 5 years old worldwide [1]. Otherwise spontaneous preterm birth (sPTB) which is the most predominant type of PTB occurs due to a sudden onset of labor [1, 6]. The aetiology of Langmia et al BMC Medical Genetics (2015) 16:63 each of which are of different genetic background, presenting a good opportunity to study the genetic disparity of preterm birth with regards to PGR gene polymorphism. In this study we aim to explore the genetic influence of PGR gene polymorphisms on the risk of PTB among Malaysian women

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