Abstract
Objective: To identify relationship between progesterone receptor
 gene polymorphism promoter region +331G/A with the risk of
 endometriosis.
 Method: An observational case-control study. Population are women
 with endometriosis and/or adenomyosis who have been performed
 laparotomy/laparoscopy at Obstetrics and Gynecology
 Department Dr. Mohammad Hoesin General Hospital Palembang,
 January-November 2013. Subjects fulfilled inclusion criteria, given
 informed consent and performed blood sampling continued by PCRRFLP.
 Results were divided into A/A genotype (homozygote mutant),
 G/A (heterozygote mutant), and G/G (homozygote wild type).
 Data were analyzed by SPSS 21.0 version.
 Result: PCR-RFLP results for+331G/A genotype were 26 (54.1%) in
 case group and 14 (26.4%) in control. +331A/A genotype was not
 found in both groups. There was significant increase risk of endometriosis
 in women carrying genotype +331G/A to those with genotype
 +331G/G with OR 3.29 (p
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