Abstract
It has been suggested that a high level of progesterone facilitates the increase in ventilation during hypoxia in animals as well as in humans (1,2). Recently, Bayliss et al. reported that progesterone stimulates respiration through a central mechanism in anesthetized cat (3). However, there have been few studies concerning the mechanisms of action of progesterone on the ventilatory response to hypoxia. In this study, we sought to determine the effects of progesterone on hypoxic ventilatory depression as well as stimulation. We hypothesized that administration of progesterone, chlormadinone acetate (CMA), may protect the deterioration of respiratory function during hypoxia. To elucidate the possible site(s) of drug action, we also compared the ventilatory response to hypoxia before and after bilateral sectioning of the carotid sinus nerves, with or without administration of progesterone in the rat.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
