Abstract
We report 2 sample cases of the use of natural progesterone in the successful treatment of premenstrual dysphoric disorder (PDD) in adolescents. Natural progesterone is physiologically milder than potent synthetic progestins in birth control pills ( Lachelin, 1991 Lachelin GC Introduction to Clinical Reproductive Endocrinology. Butterworth-Heinemann, London1991: 182-183 Google Scholar ). The only low-dose patented natural progesterone is the Prometrium® oral 100-mg capsule. Its dose size and potential for peanut oil allergy, along with potential concerns with absorption speed and fluctuating bioavailability, have caused us to use organogels ( Willimann et al., 1992 Willimann H Walde P Luisi PL Gazzaniga A Stroppolo F Lecithin organogel as matrix for transdermal transport of drugs. J Pharm Sci. 1992; 81: 871-874 Abstract Full Text PDF PubMed Scopus (161) Google Scholar ) for adolescent PDD.
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