Abstract
Production of monoclonal antibodies by hybrid cell lines1 provides a method potentially superior to conventional techniques for raising antisera2 in respect of titre and specificity. Many lines have been prepared3 that secrete antibody to cell-surface and soluble antigens and to viruses, but the products of hybridomas that recognize steroid haptens have not yet been exploited. Progesterone, the hormone of pregnancy, is essential for the establishment and maintenance of gestation in all mammalian species so far studied in detail4, and we describe here the production and characterization of an anti-progesterone monoclonal antibody which blocks the establishment of pregnancy in mice.
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