Abstract
After the administration of progesterone-4- 14C to a Digitalis lanata plant, the following radioactive metabolites were isolated: digitoxigenin, gitoxigenin, digoxigenin, 5α-pregnane-3,20-dione, 5β-pregnane-3,20-dione, 5α-pregnan-3β-ol-20-one, and Δ 5-pregnen-3β-ol-20-one. The results suggest that progesterone may be na intermediate in the biosynthesis of cardenolides from pregnenolone.
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