Abstract
A study was carried out on the effects of various steroids on the activity of leucocyte alkaline phosphatase (EC 3.1.3.1) isolated from white male rabbits. Of numerous steroids administered, progesterone was the most effective, resulting in an average 17-fold increase in enzyme activity 24 h after administration. Actinomycin or puromycin administered simultaneously with progesterone blocked the increase in enzyme activity. When administered 6 or 24 h after progesterone, actinomycin or puromycin resulsted in a rapid decrease of enzyme activity. Examination of steroid structure and increased alkaline phosphatase activity indicated that among the steroids investigated an acetyl group at position 17, and a Δ 3, 4-keto group in the A ring produced greatest increases in leucocyte alkaline phosphatase activity.
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