Abstract
Bovine serum albumin (BSA) was used to prepare microspheres and microcapsules containing progesterone. The microparticles were obtained by means of a multiple emulsion method and by thermal or chemical crosslinking. The drug loading was higher for microspheres than microcapsules and varied for the different crosslinking methods: higher with thermal than chemical crosslinking and, among the chemical crosslinkers, loading was higher for formaldehyde than 2,3-butanedione and glutaraldehyde, respectively. Drug release was well differentiated for the different systems: the microspheres released 60% of their content according to an anomalous diffusion mechanism in the shorter periods, whereas microcapsules released 60% of their content according to different kinetic trends and for longer periods of time. The duration of each kinetic period and the relative drug fraction released, depends on the crosslinking method (thermal or chemical) and the nature of the crosslinking agent. Among the systems examined, the glutaraldehyde crosslinked microspheres show the higher release rate while the thermally crosslinked microcapsules had the lowest release rate which is characterized by the longest lasting zero order period.
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