Abstract
The prolongation of QT intervals in both mothers and fetuses during the later period of pregnancy implies that higher level of progesterone may have impact on the function of cardiac ion channels. In this study, we investigated the effect of progesterone on the expression, trafficking and function of human ether-a-go-go-related gene (HERG) potassium channel, a key ion channel responsible for controlling the length of QT intervals. We found that progesterone decreased fully-glycosylated form of HERG channels in both concentration- and time-dependent manners.
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