Abstract
In vitro biochemical properties of steroid-17α-hydroxylase have been studied using rat testes and beef adrenal microsomes as enzyme sources. Steroid-17α-hydroxylase has a greater affinity for pregnenolone than for progesterone. Furthermore, pregnenolone competitively inhibits the hydroxylation of progesterone and vice-versa. The first products of the reaction, 17α-hydroxypregnenolone and 17α-hydroxyprogesterone inhibit competitively the hydroxylation of both pregnenolone and progesterone with a similar efficiency. This paper indicates that cortisol and androgens are principally synthesized through the so called Δ5 pathway.
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