Progeria: Unraveling the Premature Aging Puzzle

Abstract

Progeria is a rare genetic disorder that accelerates the aging process in affected children. This review provides acomprehensive overview of Progeria, including its clinical manifestations, genetic basis, molecular mechanisms,diagnostic methods, current treatments, and ongoing research efforts. Understanding Progeria is vital for advancingboth our knowledge of aging processes and potential therapeutic strategies. Progeria (pro-JEER-e-uh), also knownas HGPS, is an extremely rare, progressive genetic disorder. It reasons children to age rapidly, preliminary in theirfirst two years of life. Children with progeria usually appear healthy at birth. Throughout the first year, symptomssuch as slowed growth, loss of fat tissue and hair loss begin to appear. Heart complications or strokes are the finalcause of death in most children with progeria. The usual life expectancy for a child with progeria is about 15 years.Some with the condition may die younger and others may live longer, even to about 20 years. There’s no cure forprogeria, but new treatments and research show some potential for managing symptoms and complications.