Abstract
The rate of rejoining of DNA strand breaks induced by 10 krads of γ-irradiation was studied in a progeria cell strain with a markedly reduced repair capacity. An increased rate of DNA repair could be induced in these cells by co-cultivating them at high density for 8 to 24 h prior to irradiation with an established hamster cell line, a mid-passage normal human diploid strain, or a second progeria strain. Co-cultivation with late passage and terminally senescent diploid cells did not, however, appear to stimulate repair in progeria cells.
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