Abstract
Although being a complex pathology with genetic as well as non-genetic etiologies, cancer is characterized by a limited series of hallmarks including energetic metabolism reprogramming.Long ago O. Warburg unraveled a bias of tumor metabolism in favor of glycolysis, the socalled Warburg effect.
Highlights
Being a complex pathology with genetic as well as non-genetic etiologies, cancer is characterized by a limited series of hallmarks including energetic metabolism reprogramming [1]
Cellular production of ATP relies on both glycolysis and oxidative phosphorylation (OXPHOS) called mitochondrial respiration
Contributes to reactive oxygen species (ROS) production whereas intracellularly, the mitochondrial electron transport chain constitutes a major source of anion superoxide (O2.-) that is rapidly converted to hydrogen peroxide (H202)
Summary
Being a complex pathology with genetic as well as non-genetic etiologies, cancer is characterized by a limited series of hallmarks including energetic metabolism reprogramming [1]. The reprogramming of ATP production from OXPHOS to glycolysis manifests by major consequences including enhanced glucose consumption, aberrant cell death signaling, enhanced oxidative stress and autophagy. Metabolic alterations of cancer cells are generally evaluated by bulk methods including (i) Seahorse technology (ii) maximal enzymatic activities and (iii) mass spectrometry.
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