Abstract
Profiling of risk of subclinical atherosclerosis: possible interplay of genetic and environmental factors as the update of conventional approach
Highlights
Detection and treatment of patients with a high risk of atherosclerosis is an urgent medical problem
Since there is a correlation between carotid intima-media thickness (cIMT) and the degree of development of coronary atherosclerosis, and this factor has a prognostic significance in relation to the clinical manifestations of atherosclerosis, it is proposed as a surrogate marker of systemic atherosclerosis, including coronary one[3,4]
The classic cardiovascular risk factors are weakly associated with the cIMT of the carotid arteries, suggesting the presence of other factors that determine the risk of developing atherosclerosis
Summary
Detection and treatment of patients with a high risk of atherosclerosis is an urgent medical problem. Within this aspect, the identification of markers of subclinical atherosclerosis is an essential factor[1]. The thickness of the intima-media layer of the carotid arteries [carotid intima-media thickness (cIMT)], determined by high-resolution ultrasonography, is considered to be a validated and conventionally accepted non-invasive marker of subclinical atherosclerosis, that is used in clinical and epidemiological studies to assess the effect of traditional and new cardiovascular risk factors on atherosclerosis[2]. The classic cardiovascular risk factors are weakly associated with the cIMT of the carotid arteries, suggesting the presence of other factors that determine the risk of developing atherosclerosis. We aimed to explore whether geographical location, genetic and environmental factors are associated with carotid atherosclerosis in high-risk individuals, focusing on the possibility of specific interplay of genetic and environmental factors
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