Abstract
Profiling of metabolic biomarkers in the serum of prostate cancer patients
Highlights
Prostate cancer (PCa) is the second most common malignancy in men above 55 years of age and the fifth leading cause of mortality in men worldwide [1, 2]
Epidemiologic studies suggest that the use of lycopene, β-carotene, vitamins C, E, and selenium supplement may reduce the risk of advanced-stage disease [10], whereas aspirin, ibuprofen, and higher vegetable intake may decrease the risk of non-advanced-stage disease and low-grade prostate cancer [11]
Hormone therapy known as androgen deprivation therapy (ADT) is commonly used to treat advanced prostate cancer it is associated with numerous side effects that can influence the quality of life
Summary
Prostate cancer (PCa) is the second most common malignancy in men above 55 years of age and the fifth leading cause of mortality in men worldwide [1, 2]. Certain modifiable and nonmodifiable risk factors contribute to the progression of PCa [3]. Non-modifiable risk factors include age, ethnicity, and family history [4], whereas modifiable risk factors include obesity, smoking, hypertension, diabetes mellitus (DM) and dyslipidemia [5]. There are many treatment options for PCa depending on a patient's medical history, diagnosis, age, and current state of health. Keeping in view the above information, It is hypothesized that certain metabolic parameters like dyslipidemia, oxidative stress are significant for early-stage diagnosis of prostate cancer for early treatment
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