Abstract
The leaves of insulin (Tithonia diversifolia (Hemsl.) A. Gray) are native bush plants from Central America. This plant in Indonesia is often called paitan or kembang bulan. The aim of this research was to know the profile of SGPT and SGOT of male white rat (Rattus norvegicus L.) hyperglycemic after giving insulin leaf extract (Tithonia diversifolia (Hemsl.) A. Gray). This study used 20 male Wistar rats which were divided randomly into 5 groups of treatment. Those were P0 as a group of rats which was not given alloxan and insulin leaf extract, P1 as a group of rats which was given alloxan without insulin leaf extract, P2 as a group of rats which was given alloxan and glibenclamide 2 mg/Body Weight (BW)/day, P3 as a group of rats which was given alloxan and insulin leaf extract 30 mg/BW/day, P4 as a group of rats which was given alloxan and insulin leaf extract 60 mg/BW/day. Each treatment was repeated as many as 4 replications. The results of this study indicated that there was no significant differences in all variables, namely levels of SGPT, SGOT, liver weight, body weight and Hepatosomatic index (HSI), so it can be concluded that giving insulin leaf extract (Tithonia diversifolia (Hemsl.) A. Gray) of 30 mg/BW/day and 60 mg/BW/day could improve liver function of hyperglycemic male white rats (R. norvegicus L.).
Highlights
Liver is an organ that plays an important role in detoxification to convert toxic compounds into non-toxic compounds (Chiang, 2014)
This study aims to analyze liver function after giving various doses of insulin leaf extract (Tithonia diversifolia (Hemsl.) A
The Serum Glutamate Pyruvat Transaminase (SGPT) and Serum Glutamate Oxalacetate Transaminase (SGOT) in male white rat (Rattus norvegicus L.) hyperglycemic treated with insulin leaf extract (Tithonia diversifolia (Hemsl.) A
Summary
Liver is an organ that plays an important role in detoxification to convert toxic compounds into non-toxic compounds (Chiang, 2014). Liver can be damaged during hyperglycemic conditions due to the increase of blood glucose levels exceeding normal (Sari et al, 2010) It is characterized by the presence of blood glucose more than 126 mg/dL (Prasetyo et al, 2016), which can cause glucose availability in cells decreases so that it can trigger the occurrence of gluconeogenesis in liver cells (Agunbiade et al, 2012). These conditions over a long period of time can lead to increase Reactive Oxygen Species (ROS) compounds that can bind to hepatocyte structures, thereby able to cause hepatocyte damage which is begin with degeneration, up to cellular necrosis (Maulida et al, 2013). Giving herbal ingredients through oral with specific doses can interfere liver function (Navarro et al, 2017)
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