Profile of liver biopsy in tertiary care hospital–1 year data

Abstract

S 21 ANNUAL CONFERENCE—2013 M isella n eo u s patients. Intrahepatic cholestasis of pregnancy (IHCP) was diagnosed by raised serum bile acid (>10mmol/L). Preeclampsia and Acute fatty liver of pregnancy were diagnosed by standard criteria. Results: Seventy eight patients were studies (median age 27 year range 20-42years). Eighty three percent (65/78) were in the third trimester of pregnancy. Spectrum of liver diseases was as follows IHCP was 58.9% (46/78), viral hepatitis 21.7% (17/78), preeclampsia 10.2% (8/78), hyperemesis 2.5%(2/78), AFLP 2.5%(2/78), Chronic Liver disease 2.5%(2/78). Among 17 patients with viral hepatitis, 11 had incidental HBsAg positivity, 5 with hepatitis E and 2 with hepatitis A presented as acute hepatitis. Maternal mortality was seen in 4 cases (2 AFLP, 2 preeclampsia) in the third trimester. Preterm delivery was observed in 8 patients, out of which 6 had IHCP (17.3%). Low birth weight was seen in 22 patients of whom 18 had IHCP (39.1%). There were 6 fetal deaths (2-AFLP, 2-preclampsia, 1-acute liver failure (hepatitis E related) and 1-CLD). The overall maternal and fetal death was 5.22 % and 7.69% respectively and was seen in AFLP, preeclampsia and ALF patients. Conclusions: IHCP is the commonest cause of deranged LFT during pregnancy. Preterm labor is common in IHCP. AFLP and preeclampsia were associated with poor maternal and fetal outcome. Corresponding author: Mohan B Goyal. E-mail: mohandr77@gmail.com PROFILE OF LIVER BIOPSY IN TERTIARY CARE HOSPITAL–1 YEAR DATA Pravir Amrutrao Gambhire, Ashok Rohidas Mohite, Samit Sampat Jain, Dharmesh Kirit Shah, Amol Ajit Khot, Piyush Somani, Pravin Rathi, Anjali Amrapurkar Departments of Gastroenterology and Pathology, BYL Nair Hospital