Abstract

HIV-TB co-infection still becomes a health problem in Indonesia, including in Nabire district, Papua province, which has the highest number of cases. HIV and TB infections are closely related and affect the epidemiology of one another. This study aims to determine the profile description of HIV-TB co-infected patients in Nabire. This research is a descriptive study with a cross-sectional design on 90 people with HIV/AIDS selected consecutively. Data were analyzed univariately and presented in the form of a frequency distribution table. The results showed that of 55 HIV/AIDS co-infected TB patients, almost all (90.9%) were Papuan ethnic, 70.9% were female and aged 30 to 49 years (50.9%) with a mean of 31.309.36 years. The majority of HIV-TB co-infected patients were married (63.6%), holding secondary education (58.2%), working (67.3%), engaging in sexual activity after 17 years of age, only having one sexual partner, and did not use drugs or obtain blood transfusions. The clinical profile of HIV-TB patients showed that 67.3% of the patients were with baseline CD4 count ≤350 cells/mm3, 64.8% had CD4 count at the time of study >350 cells/mm3, and viral load values fewer than 5000 copies/ml (87.3%). The therapy most widely received for patients with HIV-TB coinfection was the combination of ARV 3TC+EFV+TDF (76.4%). The most common clinical symptoms of HIV/AIDS patients were weight loss (56.4%), cough (40%), recurrent oral thrush (36.4%), chickenpox (32.7%), and tuberculosis lymph nodes (18.2%).

Highlights

  • Tuberculosis (TB) and HIV/AIDS are infectious diseases that still become a global health problem, including in Indonesia

  • The total number of respondents with HIV/AIDS participating in this study was 90 people, 45 people from Bumi Wonorejo Health Centre, and 45 people from Santo Rafael Clinic

  • Co-infection or secondary infection can be a major cause of morbidity and mortality in people with HIV/AIDS

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Summary

Introduction

Tuberculosis (TB) and HIV/AIDS are infectious diseases that still become a global health problem, including in Indonesia. Tuberculosis is the most significant cause of morbidity and mortality in people living with HIV/AIDS (PLWHA). These two diseases interact synergistically to accelerate immunological decline and result in death if untreated. PLWHA are more susceptible to TB infection than those who do not have HIV/AIDS [1,2]. In 2015 an estimated 1.14 million new HIV-TB coinfection cases and 400,000 thousand deaths were caused by HIVTB coinfection. The cumulative decline in TB cases from 2015 to 2019 was only 9% (from 142 to 130 new cases per 100,000 population), including a 2.3% drop between 2018 and 2019 [4]

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