Abstract
Profile of Anti-Chlamydia Immune Responses in Complicated (Infertile) and Non-complicated (Fertile) Genital Infections
Highlights
C. trachomatis genital infection is the most common bacterial Sexually-Transmitted Disease (STD) worldwide and in women Pelvic Inflammatory Disease (PID), ectopic pregnancy and infertility are serious complications that are of considerable public health concern
And qualitatively measurable humoral and T cell-mediated immune responses are associated with genital chlamydial infection; modulatory strategies to skew these responses toward protective immune effectors mediating resolution of an infection or acquisition of immunity and protection from re-infection are among the challenging issues in the continuing effort to develop an efficacious chlamydial vaccine
Clinical studies in humans and experimentation in animal infection models have revealed that immunity to C. trachomatis correlates with a strong CD4 T helper type 1 (Th1) response and a complementary antibody response; the major role of anti-chlamydial antibody response is to foster a rapid and robust memory T Cell Mediated Immune (CMI) response during reinfections and possibly the neutralization of infectious particles [1,2,3,4,5]
Summary
C. trachomatis genital infection is the most common bacterial Sexually-Transmitted Disease (STD) worldwide and in women Pelvic Inflammatory Disease (PID), ectopic pregnancy and infertility are serious complications that are of considerable public health concern. The results revealed that infected infertile mice exhibited lower systemic anti-chlamydial total IgG levels than animals with comparable microbiological shedding of chlamydiae but protected from infertility by treatment with the pan-caspase inhibitor Z-VAD-FMK.
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