Abstract
Benzo(a)pyrene (BaP) is one of several examples of polycyclic aromatic hydrocarbons that come from incomplete combustion of organic materials.BaP compound is used in research to induce fibrosarcoma.In general, patients with cancer will experience a reduction in body weight. This study aims to determine the body weight profile, the time it takes to cause fibrosarcoma, and the mortality rate of male Sprague Dawley rats after injection with BaP. In this study, 18 rats were used with two treatments.Rats in treatment 0 (P0) were not treated, while rats in treatment I (PI) were injected with BaP 0.3% in 0.1 mL oleum olivarumten times given gradually at two-day intervals via subcutaneous. There were six and 12 rats, respectively, P0 and PI. BaP solution is prepared by dissolving in oleum olivarum, mixing, and stirring until homogeneous. The rats were weighed at the beginning of the study and then carried out routinely once a weekfor 19 weeks of research. At the beginning of the study, the average body weight of rats at P0 and PI were 121.43 ± 7.04 g and 131.49 ± 16.31 g, respectively. The mean body weight of the rats at P0 and PI from the first week to the 19th were178.53 ± 29.97 g and 159.20 ± 14.24 g, respectively. The time taken to inducefibrosarcoma was 85.5 ± 17.6 days. The mortality rate in treatment P0 was 0% and PI treatment was 8.33%.From the results of this study, it can be concluded that giving BaP significantly reduces the body weight profile of rats and has a mortality rate of 8.33%.
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