Abstract
Objective. – The authors had for aim to evaluate the place of multi-drug resistant bacteria (MDR) in nosocomial bacteremia. Materials and methods. – A retrospective study was carried out at the Microbiology laboratory of Charles Nicolle hospital of Tunis (2001–2003). One hundred and ninety-five isolated MDR [third generation cephalosporin resistant enterobacteria, methicillin–resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii and Pseudomonas aeruginosa resistant to ceftazidime and imipenem]. An automated system was used to detect bloodstream infections. Microorganism identification was performed by conventional methods and antibiotic susceptibilities were determined by the disk diffusion method. Results. – MDR bacteria were resistant to third generation cephalosporins (29%), A. baumannii (24%), P. aeruginosa (24%), and MRSA (10%). ERC 3G were resistant to aminosides and fluorquinolones. A. baumannii and P. aeruginosa had high resistance rates. Associated resistance rates in MRSA were moderate. Conclusion. – MDR bacteria are of great concern in our hospital. This situation emphasizes the importance to maintain rigorous measures of hygiene as well as adapted antibiotic prescriptions.
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