Abstract
The current study was designed to evaluate the efficiency of broccoli plant in therapy of PCOS that induced for the first time by testosterone andriol (T.A).
 Forty-eight immature female rats (21 days old) were divided into 6 groups (8 rats each) as follows: G1, animals were injected with sesame oil for 39 cascade days (control). G2, animals were injected with 1mg/100g b.w of T.A for 39 cascade days. G3, animals were injected with 1mg/100g b.w of T.A gathered with gavaged broccoli juice (b.j) for 39 cascade days. G4, animals were injected with sesame oil for cascade 39 days at the end of last injection were gavaged with d.w for 30 cascade days. G5, animals were injected with 1 mg/100g b.w of T.A for 39 cascade days and at the end of last injection were gavaged with d.w for 30 cascade days. G6, animals were injected with 1mg/100g b.w of T.A for 39 days and at the end of the last injection were gavaged with b.j for 30 cascade days. T.A-induced PCOS rats (G2 and G5) in comparison with controls (G1 and G4) exhibited that had a significant (P≤0.01) increase in the b.w, ovarian, uterine and fat pads weights as well as the fat cells diameter. Additionally, these groups had acyclicity, high numbers of ovarian cysts, atretic and preantral follicles in the ovaries, lowering the number and the diameter of C.L., and uterine changes. The levels of T, E and LH, an insulin, glucose, LDL, cholesterol in the serum were increased whereas the levels of FSH, LDH were decreased.
 Therefore, T.A PCOS model could be appropriated for studied all the features of syndrome i.e, ovarian, metabolic and endocrinologiccal disturbances. Whereas all these measurements of G3 and G6 were ameliorated and recovered into their normalcy. Our findings have shown the benefit of consuming broccoli in the protection (G3) and prevention (G6) of PCOS.
Highlights
Polycystic ovary syndrome (PCOS) was discovered by Stein and Leventhal at 1935, so it was called Stein-Levenathal syndrome [1]
There is consensus that refers to the androgen excess, insulin resistance and gonadotropin dynamic are the underling defects in PCOS [6]
PCOS symptoms were similar to those of previous rodent models that using other substances and programs [21]. These symptoms involved several features i.e, reproductive, metabolic and endocrinological abnormalities, which associated with human PCOS
Summary
Polycystic ovary syndrome (PCOS) was discovered by Stein and Leventhal at 1935, so it was called Stein-Levenathal syndrome [1]. Whereas Yuan et al [11] reported that the BAt-induced diponectin protein will be a new approach in curing of PCOS These pharmacotherapies were used to manage just some features related with PCOS, either hyperandrogenism and restor ovulation or inhibiting of androgen action or curing of hyperinsulinemia or treatment of hirsutism and acne or for reduction of LDL and increment of HDL. As well as broccoli is effective in reducing of cholesterol levels [19] It has diinodlymethane (DIM) compound that discriminated with antiandrogenic properties which used as androgen antagonist for therapy of prostate cancer [14]. The goal of this study was to determine the impact of broccoli plant in treatment T.A-induced PCOS in rats, as trying to find a safe and alternative therapy of PCOS with minimal side impacts instead of medicinal and surgical methods
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