Abstract
Abstract γ-Linolenic acid (GLA) plays a crucial role in brain function and normal growth and development. High percentage of the population cannot effectively produce GLA, resulting in the use of GLA dietary supplements. Several oleaginous fungi can produce low level of GLA. The present study aimed to improve the production of GLA using physical mutagenesis. Spore suspensions of Cunninghamella echinulata were treated with pulsed high magnetic field. A total of 64 strains were isolated and screened using Nile red staining and fluorescence detection. Three mutants were selected after fermentation screening. GLA yields of Mut-29, Mut-15, and Mut-64 increased by 46.2%, 23.1%, and 19.2%, respectively, compared with that of the parent strain. Biomass, lipid content and yield, GLA content, and GLA yield of Mut-29 increased significantly (P
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