Abstract
Summary1. Erythrocytes from 2 individuals with sickle cell anemia, when injected into rabbits, produced antisera which agglutinated erythrocytes of 19 individuals with sickle cell anemia, but not those of 21 individuals with sickle cell trait nor those of 124 normal individuals.2. Such sera may be useful in the differential diagnosis between sickle cell anemia and sickle cell trait.3. The presence of agglutinin antibody has been demonstrated in the sera of all of 13 patients with sickle cell anemia. This finding may explain the hemolysis which is characteristic of this disease.4. Of 11 patients with sickle cell trait, definite agglutinin antibody was demonstrated in the sera of 4, and doubtful agglutinin antibody in 2.
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