Production of solid lipid nanoparticles with a supercritical fluid assisted process

Abstract

In this work, a supercritical fluid continuous process, the Supercritical Assisted Injection in a Liquid Antisolvent (SAILA), was proposed for the production of solid lipid nanoparticles (SLNs).SLNs of soy lecithin, cholesterol and stearic acid were produced in this work. Acetone and ethanol were used as solvents. The effect of lipid concentration on particles size distribution and morphology was studied. SLNs with mean dimensions included between 158 ± 53 nm and 326 ± 169 nm were obtained for soy lecithin particles, between 151 ± 74 nm and 207 ± 57 nm for cholesterol and from 364 ± 77 nm to 462 ± 88 nm for stearic acid particles. All the suspensions were stable over 30 days of observation.