Abstract
Titanium dioxide nanoparticles (TiO2NPs) are popular materials with high annual production and increasing applications in different fields. In the current research, we synthesized TiO2NPs with the help of the reducing potential of trans-ferulic acid (FA). FA-TiO2NPs are principally characterized by X-Ray Diffraction (XRD), Fourier Transform-Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), Field-Emission Scanning Electron Microscopy (FE-SEM), Energy Dispersive X-Ray Analysis (EDX), and Thermogravimetric (TGA) techniques. Then, their biomedical properties were investigated by in vitro hemolysis, anti-inflammatory, and cytotoxicity tests. According to physiochemical analysis, FA-TiO2NPs had mostly rod-shaped morphology with a rutile crystallographic phase. These NPs were non-hemolytic with high anti-denaturation and membrane stabilization activity and thus excellent in vitro anti-inflammatory effects. FA-TiO2NPs decreased the cell viability of A375 (melanoma cell line), MCF-7 (breast cancer cell line), and human skin fibroblast (normal cell line) in a dose-dependent manner. The IC50 values of FA-TiO2NPs were above 12.5, 25, and 50 µg/mL against A375, MCF-7, and skin fibroblast cell lines, respectively. In this study, we demonstrated the biocompatibility and valuable potential of FA-TiO2NPs in biomedical applications.
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