Abstract
The metal radionuclides <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">60</sup> Cu (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sub> = 23 min), <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">52</sup> mMn (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sub> = 21 min) and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">94</sup> mTc (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sub> = 53 min) can be used to label tracers of high clinical and preclinical interest in PET studies. Furthermore, as they emit prompt gamma-rays right after the positron emission, they can be distinguished from standard positron emitters like <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> F, enabling multiplexed PET (mPET) imaging. In this work we studied the feasibility of their production using a relatively low-energy (10 MeV) proton beam from a linear accelerator. These radionuclides were produced by bombardment on target foils of natural Nickel, Chromium and Molybdenum respectively. After activation, the emissions from the foils were analyzed by a Ge spectrometer and the absolute activity for each produced species was obtained. The activity generated was in agreement with the expected cross-sections and the isotopes present in the samples. These results The metal radionuclides <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">60</sup> Cu (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sub> = 23 min), <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">52</sup> mMn (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sub> = 21 min) and <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">94</sup> mTc (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/2</sub> = 53 min) can be used to label tracers of high clinical and preclinical interest in PET studies. Furthermore, as they emit prompt gamma-rays right after the positron emission, they can be distinguished from standard positron emitters like <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> F, enabling multiplexed PET (mPET) imaging. In this work we studied the feasibility of their production using a relatively low-energy (10 MeV) proton beam from a linear accelerator. These radionuclides were produced by bombardment on target foils of natural Nickel, Chromium and Molybdenum respectively. After activation, the emissions from the foils were analyzed by a Ge spectrometer and the absolute activity for each produced species was obtained. The activity generated was in agreement with the expected cross-sections and the isotopes present in the samples. These results show the feasibility of production of these radionuclides with a 10 MeV proton beam.show the feasibility of production of these radionuclides with a 10 MeV proton beam.
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